The closest alternative to Mixtral 8x22B Instruct is Mistral Medium 3.5 — comparable intelligence (39.2 vs —); for a cheaper option, Qwen3.7 Max runs $1.25/M vs $2.00/M; for more speed, Morph V3 Large hits 3.1k t/s; and the best open-weight substitute is MiniMax M3.
Mistral Medium 3.5 is the closest alternative to Mixtral 8x22B Instruct, with an Intelligence Index of 39.2 (Mixtral 8x22B Instruct scores —) at $1.50 per million input tokens.
Yes — Qwen3.7 Max costs $1.25 per million input tokens versus $2.00 for Mixtral 8x22B Instruct, while staying within ~8 points of its Intelligence Index.
MiniMax M3 is the strongest open-weight alternative to Mixtral 8x22B Instruct — downloadable from Hugging Face and self-hostable, scoring 54.7 on intelligence.