The closest alternative to Qwen2.5 72B Instruct is GPT-4.1 Nano — comparable intelligence (9.6 vs 9.6); for a cheaper option, GPT-5.6 Luna runs $0.100/M vs $0.360/M; and the best open-weight substitute is Kimi K3.
GPT-4.1 Nano is the closest alternative to Qwen2.5 72B Instruct, with an Intelligence Index of 9.6 (Qwen2.5 72B Instruct scores 9.6) at $0.100 per million input tokens.
Yes — GPT-5.6 Luna costs $0.100 per million input tokens versus $0.360 for Qwen2.5 72B Instruct, while staying within ~8 points of its Intelligence Index.
Kimi K3 is the strongest open-weight alternative to Qwen2.5 72B Instruct — downloadable from Hugging Face and self-hostable, scoring 57.1 on intelligence.